Airways exposure of bacterial superantigen SEB enhances bone marrow eosinophil population and facilitates its egress to blood and lung tissue

A.S. Pinheiro-Torres, A.P. Ferreira-Duarte,W.M. Takeshita, V.O. Gushiken, I.A. Roncalho-Buck,G.F. Anhê,E. Antunes,I.A. DeSouza

Life Sciences（2021）

引用 3|浏览9

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摘要

•Airways exposure to SEB causes blood, lung eosinophilia and bone marrow (BM) accumulation of mature eosinophils•SEB airways exposure increases BM eosinophils adhesion to VCAM-1 and ICAM-1•SEB airways exposure enhancement BM eosinophils CCR3 expressionn•SEB induces BM elevations of eotaxin, IL-5, IL-4, IL-3 and IL-7.•Our results contribute to elucidate BM events during SEB-induced lung inflammation

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关键词

Cell trafficking,Lung inflammation,CCR3 and Eotaxin,ICAM-1,VCAM-1,VLA4

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