Staphylococcus Aureus Biofilm Eradication By The Synergistic Effect Exerted By Peg-Coated Silicon Dots Immobilized In Silica Films And Light Irradiation

NANOTECHNOLOGY(2021)

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摘要
Immobilization of PEG-covered silicon dots, PEGSiDs, on glass substrates was performed following a simple strategy involving particle embedding by a sol-gel process forming a silica film on glass slides. The obtained films, denoted as fSiO(x)-PEGSiD, constitute a water-wettable, strongly supported, photoluminescent glass coating. The films showed high capacity for photosensitizing singlet oxygen (O-1(2)) in the UVA when immersed in water. Staphylococcus aureus colonies formed on fSiO(x)-PEGSiDs modified glasses revealed the inhibition of bacterial adhesion and bacterial growth leading to the formation of loosely-packed and smaller S. aureus colonies. Upon 350 nm light irradiation of the biofilmed fSiO(x)-PEGSiDs -modified glasses, S. aureus growth was inhibited and bacteria killed reducing the number of living bacteria by three orders of magnitude. Eradication of attached bacteria was achieved by the synergistic effect exerted by a less adherent fSiO(x)-PEGSiDs surface that inhibits biofilm formation and the ability of the surface to photosensitize O-1(2) to kill bacteria.
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关键词
photodynamic inactivation, UVA-irradiation, singlet molecular oxygen, microporous films, bacterial adhesion inhibition, bactericidal effect
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