Experimental glioma with high bHLH expression harbor increased replicative stress and are sensitive toward ATR inhibition.

Marilin Sophia Koch,Stefan Czemmel,Felix Lennartz,Sarah Beyeler, Srinath Rajaraman,Justyna Magdalena Przystal,Parameswari Govindarajan,Denis Canjuga,Manfred Neumann,Patrizia Rizzu,Stefan Zwirner,Michael Stefan Hoetker,Lars Zender,Bianca Walter,Marcos Tatagiba,Olivier Raineteau, Peter Heutink,Sven Nahnsen,Ghazaleh Tabatabai

Neuro-oncology advances（2020）

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摘要

Gliomas overexpressing (b)HLH TFs are sensitive toward inhibition of the ATR kinase. The combination of ATR inhibition plus temozolomide or radiation therapy in this molecular subgroup are warranted.

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关键词

CAGE,DDR,E47,RNA-Seq,bHLH transcription factors

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