Modulating Microenvironments for Treating Glioblastoma

Purpose of Review This review focuses on the development and progression of glioblastoma through the brain and glioma microenvironment. Specifically, we highlight how the tumor microenvironment contributes to the hallmarks of cancer in hopes of offering novel therapeutic options and tools to target. Recent Findings The hallmarks of cancer represent elements of cancer that contribute to the disease’s malignancy, yet elements within the brain tumor microenvironment, such as other cellular types as well as biochemical and biophysical cues that can each uniquely affect tumor cells, have not been well-described in this context and serve as potential targets for modulation. Summary Here, we highlight how the brain tumor microenvironment contributes to the progression and therapeutic response of tumor cells. Specifically, we examine these contributions through the lens of Hanahan and Weinberg’s “Hallmarks of Cancer” in order to identify potential novel targets within the brain that may offer a means to treat brain cancers, including the deadliest form of brain cancer, glioblastoma.