Sulfonamide antibiotics inhibit RNAi by binding to human Argonaute protein 2 PAZ.

Yoshiaki Kitamura,Mahmoud Kandeel, Tomoya Kondo, Akihiro Tanaka, Yohei Makino,Noriko Miyamoto,Aya Shibata,Masato Ikeda,Yukio Kitade

Bioorganic & medicinal chemistry letters（2020）

引用 3|浏览7

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摘要

We found that sulfisomidine, a sulfonamide antibiotic, potently binds to the Piwi/Argonaute/Zwille (PAZ) domain of human Argonaute protein 2 and inhibits RNA interference (RNAi). To elucidate the effect on RNAi of strong affinity of the 3'-ends in small interfering RNA (siRNA) to the PAZ domain, chemically modified siRNAs bearing sulfisomidine at the 3'-end were synthesized.

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