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Skp2 regulates DNA damage repair and apoptosis via interaction with Ku70

Jing Jia,Dongmei Yan,Yizhe Wang,Mengyuan Liu,Zhenyu Jia, Lei Luo,Juan Ren,Jianfei Fang,Haining Yuan,Yanyan Zhao,Yongfei Song,Yihui He,Xiaoju Wang

Experimental Cell Research（2020）

Cited 5|Views18
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Abstract
•Ku70 could interact with Skp2 via its C-terminal.•Skp2 knockdown might increase the cellular apoptosis by Bax signaling way.•Skp2 knockdown could increase DNA damage.•Skp2 might regulate Ku70 protein stability and function via post-translational modification.
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Key words
Cervical cancer,Ku70,Protein interaction,Post-translational modification,S-phase kinase–associated protein2
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