Sarcopenia – Molecular mechanisms and open questions
Ageing Research Reviews(2021)
Abstract
•Sarcopenia, a muscle-wasting syndrome during normal aging, is mainly characterized by loss of muscle strength and mass.•Several molecular mechanisms have been described as causes for sarcopenia.•Main mechanisms represent loss of proteostasis, mitochondrial dysfunction and inflammatory disturbances.•Open questions consider the role of muscular fat infiltration, fibre-specific regulation and therapeutic impact of the diet.
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Key words
Molecular pathways,Proteostasis,Proteasome,Autophagy,Mitochondria, Muscle fibre composition
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