Screen-printed Electrode Modified with Magnetic Core-shell Nanoparticles for Detection of Chlorpromazine

In the present study, magnetic core-shell manganese ferrite nanoparticles (MCMNP) were synthesized and used for construction of a magnetic core-shell manganese ferrite nanoparticles modified screen-printed carbon electrode (MCSNP-SPCE). Cyclic voltammetry was used to study the electrochemical behavior of chlorpromazine (CPZ) and its determination was conducted by applying square wave voltammetry (SWV). The MCSNP-SPCE in comparison with bare SPCE exhibited enhanced electrocatalytic activity toward the oxidation of CPZ. A single irreversible oxidation peak was observed at a potential of 500 mV and 630 mV on the MCSNP-SPCE and bare SPCE, respectively. Under the optimized conditions, the anodic peak current of CPZ recorded by SWV varies linearly with CPZ concentration in the range 0.25-60 mu M with a detection limit of 0.08 mu M. The MCSNP-SPCE was used for quantitative analysis of CPZ in tablet and urine samples and the results indicate the feasibility of the amperometric method for CPZ analysis in routine detection.