Subcellular Location of Tirapazamine Reduction Dramatically Affects Aerobic but Not Anoxic Cytotoxicity.

Chris P. Guise,Maria R. Abbattista,Robert F. Anderson,Dan Li,Rana Taghipouran,Angela Tsai, Su Jung Lee,Jeff B. Smaill,William A. Denny,Michael P. Hay,William R. Wilson, Kevin O. Hicks,Adam Patterson

Molecules（2020）

引用 5|浏览43

关键词

tirapazamine,DNA-targeted cytotoxin,hypoxia-activated prodrug,cytochrome P450 oxidoreductase,cell nucleus,endoplasmic reticulum,cell membrane,DNA damage-response

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