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SP1 activated-lncRNA SNHG1 mediates the development of epilepsy via miR-154-5p/TLR5 axis

Meng-Wen Zhao, Wen-Jie Qiu,Pu Yang

Epilepsy Research（2020）

Cited 12|Views3
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Abstract
•Elevated SNHG1 was observed in the mouse model of epilepsy.•SNHG1 knockdown alleviated Mg2+ free-induced neuronal injury via inhibiting cell apoptosis in vitro.•SNHG1 acted as a sponge of miR-154-5p.•SNHG1 promoted neuronal injury via miR-154-5p/TLR5.•SP1 transcriptionally activated SNHG1.
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Epilepsy,lncRNA SNHG1,miR-154-5p,SP1,TLR5
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