Quest For The Crypto-Phosphoproteome
CHEMBIOCHEM(2021)
摘要
Protein phosphorylation is one of the most studied post-translational modifications (PTMs). Despite the remarkable advances in phosphoproteomics, a chemically less-stable subset of the phosphosites, which we call the crypto-phosphoproteome, has remained underexplored due to technological challenges. In this Viewpoint, we briefly summarize the current understanding of these elusive protein phosphorylations and identify the missing pieces for future studies.
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关键词
binding domains, kinases, phosphatases, phosphoproteome, protein phosphorylation
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