Transformation From Adenocarcinoma To Squamous Cell Carcinoma Associated With Long-Term Administration Of Egfr-Tkis
MOLECULAR AND CLINICAL ONCOLOGY(2020)
Abstract
Although patients with non-small cell lung cancer exhibiting EGFR mutations generally respond to tyrosine kinase inhibitors (TKIs), the majority of patients acquire resistance similar to 1 year after treatment. EGFR T790M mutations, MET or HER2 amplifications and phenotypic transformations contribute to the mechanism of EGFR-TKI resistance. The transformation of small cell lung cancer frequently occurs, although few convert to squamous cell carcinoma associated with the administration of EGFR-TKIs. The current study reports a case of EGFR-mutated adenocarcinoma of the lung that transitioned to squamous cell carcinoma in association with long-term EGFR-TKIs administration.
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Key words
epidermal growth factor receptor tyrosine kinase inhibitor, resistance, salvage surgery, squamous cell carcinoma transformation, MET amplification
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