Papillary thyroid carcinoma with a high tumor mutation burden has a poor prognosis
International Immunopharmacology(2020)
Abstract
•Papillary thyroid carcinoma with a high tumor mutation burden has a poor prognosis.•High-TMB patients showed lower immune cell infiltration.•High-TMB patients showed more tumor-promoting immune cells and fewer antitumor immune cells in proportion.•Immunotherapy could be a viable option for advanced PTC.
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Key words
Papillary thyroid carcinoma (PTC),Tumor mutation burden (TMB),Immune infiltration,Immunotherapy,Prognosis
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