Liposomes embedded within fibrin gels facilitate localized macrophage manipulations within nerve

•Clodronate liposomes target macrophages, not other cells within nerve.•Liposomes can be embedded within fibrin gels for extended retention of liposomes.•Liposomes embedded within fibrin gels are phagocytosed by macrophages in vivo.•Clodronate liposomes embedded within fibrin gels can deplete macrophages locally.•Local macrophage depletion within a nerve gap affects regeneration across the gap.