Expression profiling of DNA methyl transferase I (DNMT1) and efficacy of a DNA-hypomethylating agent (decitabine) in combination with chemotherapy in osteosarcoma

Parunya Chaiyawat,Nutnicha Sirikaew,Piyaporn Budprom,Jeerawan Klangjorhor,Areerak Phanphaisarn,Pimpisa Teeyakasem,Jongkolnee Settakorn,Dumnoensun Pruksakorn

Journal of Bone Oncology（2020）

引用 4|浏览2

暂无评分

摘要

•This study provides population-based expression pattern of DNMT1 which is an actionable target for osteosarcoma treatment.•Overexpression of DNMT1 was observed in osteosarcoma, in which levels of DNMT1 were consistent in biopsy and post-chemotherapy tissues.•We highlight synergistic effect of drug targeting DNMT1 enzyme (decitabine) and chemotherapy for the treatment of osteosarcoma.

查看译文

关键词

Osteosarcoma,DNA methylation,Immunohistochemistry,Drug combinations,Drug Synergism

AI 理解论文

溯源树

样例

生成溯源树，研究论文发展脉络

Chat Paper

正在生成论文摘要