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Melatonin prevents LPS-induced epithelial-mesenchymal transition in human alveolar epithelial cells via the GSK-3β/Nrf2 pathway

Zhenxing Ding,Xu Wu,Yueguo Wang,Shuang Ji,Wenying Zhang,Jiaying Kang,Jiajia Li,Guanghe Fei

Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie（2020）

Cited 31|Views11
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Abstract
•LPS increase the generations of ROS, further induce EMT in alveolar epithelial cells.•Activating Nrf2, an important antioxidant sensor, could block EMT by regulating ROS.•Melatonin attenuates ROS and prevents EMT via the GSK-3β/Nrf2 pathway.
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Key words
ALI,EMT,LPS,ROS,Nrf2,HO-1,PI3K,AKT,GSK-3β
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