TET1 Interacts Directly with NANOG via Independent Domains Containing Hydrophobic and Aromatic Residues

•TET1 and NANOG interact via multiple independent binding regions.•TET1 and NANOG interactions are mediated by aromatic and hydrophobic residues.•TET1 residues that bind NANOG are highly conserved in mammals.•Co-localisation of TET1 and NANOG on chromatin is enriched at NANOG target genes.•NANOG and TET1 have regulatory roles in maintaining and reprogramming pluripotency.