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Emergent Coordination of the CHKB and CPT1B Genes in Eutherian Mammals: Implications for the Origin of Brown Adipose Tissue

Bhavin V Patel,Fanrong Yao,Aidan Howenstine,Risa Takenaka,Jacob A Hyatt,Karen E Sears,Brian M Shewchuk

Journal of Molecular Biology（2020）

Cited 5|Views14
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Abstract
•BAT thermogenesis is fueled by CPT1B-dependent fatty acid oxidation.•The CPT1B gene is conjoined to the CHKB gene exclusively in eutherians.•CHKB-CPT1B is transcribed within a unitary epigenetic domain in eutherians.•These genes are independently expressed from discrete domains in opossum.•CHKB-CPT1B conjoinment precipitated the emergence of BAT in eutherians.
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brown adipose tissue,CHKB,CPT1B,fatty acid oxidation,conjoined gene
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