Changes In The Body Composition And Nutritional Status After Long-Term Rifaximin Therapy For Hyperammonemia In Japanese Patients With Hepatic Encephalopathy

Objective Rifaximin has become available for treating hyperammonemia in patients with hepatic encephalopathy. This study analyzed the changes in the body composition and nutritional status after long-term rifaximin therapy.Methods Twenty-one patients who underwent rifaximin therapy at 1,200 mg/day for more than 24 weeks were evaluated for the changes in the controlling nutritional status (CONUT) scores for the nutritional assessment, albumin-bilirubin (ALBI) scores for the liver function assessment, and skeletal muscle index (SMI) for the body composition assessment.Results There were 17 men and 4 women, with a mean age of 67.14 +/- 8.32 years. Eleven cases had a portosystemic shunt (52.3%), and 10 had hepatocellular carcinoma (47.6%). The Child-Pugh class was A in 9 cases (42.9%), B in 9 cases (42.9%), and C in 3 cases (14.2%). The blood ammonia levels in the rifaximin group improved significantly upon rifaximin therapy, from 124.76 +/- 28.68 mu g/dL at baseline to 47.00-114.43 mu g/dL after 2 weeks (p<0.001) and 49.81 +/- 15.02 mu g/dL after 24 weeks (p<0.001). The CONUT scores improved significantly during rifaximin therapy, from 6.47 +/- 3.25 at baseline to 3.33 +/- 2.65 after 24 weeks (p= 0.0007). The ALBI scores also improved significantly from -0.39 +/- 1.89 at baseline to -2.201-0.55 after 24 weeks (p=0.0002). The SMI scores showed that the body composition had been maintained in response to rifaximin therapy (50.20 +/- 7.67 at baseline and 51.29 +/- 7.62 after 24 weeks).Conclusion Rifaximin administration for hepatic encephalopathy improved the CONUT and ALBI scores. It may have a secondary effect on the improvement in the nutritional status and hepatic reserve.