Pre-treatment twice with liposomal clodronate protects against acetaminophen hepatotoxicity through a pre-conditioning effect

Melissa M Clemens,Joel H Vazquez,Stefanie Kennon-McGill,Sandra S McCullough,Laura P James,Mitchell R McGill

Liver Research（2020）

Cited 2|Views14

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Abstract

We conclude that multiple pre-treatments with LC protect against APAP by accelerating glutathione re-synthesis through glutamate-cysteine ligase. Investigators using two or possibly more LC pre-treatments to deplete macrophages, including peritoneal macrophages, should be aware of this possible confounder.

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Key words

Acetaminophen (APAP),Acute liver failure (ALF),Damage-associated molecular patterns (DAMPs),Drug-induced liver injury,Liposomal clodronate (LC),Kupffer cells,Nuclear factor erythroid 2-related factor (Nrf2),Sterile inflammation,Stress response

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