Tyrosinase enzyme: 2. Inhibitors from natural and synthetic origins

In this work there are tackled in a general way the tyrosinase inhibitor compounds, the limiting enzyme and the fundamental key for the skin pigmentation control in human beings. The main characteristics of the depigmenting agents used in the medical practice are depicted. Besides, the compounds studied until nowadays are showed, which are grouped taking into account its origin: naturals, synthetics and drug with other therapeutic uses, discovered with inhibitory activity against the enzyme. Finally the last advances in the cheminformatic and molecular modeling field related with the study of the enzyme and its inhibitors are discussed.