Effects of pine bark procyanidins extract on blood glucose, blood lipid and antioxidation in diabetic mice
PROCEEDINGS OF THE 2017 5TH INTERNATIONAL CONFERENCE ON MACHINERY, MATERIALS AND COMPUTING TECHNOLOGY (ICMMCT 2017)(2017)
摘要
Objective: To study the effects of pine bark procyanidins extract on blood glucose, blood lipid and antioxidation in diabetic mice. Methods: Diabetic mice model was made by intraperitoneal injection of Streptozotocin (STZ). Diabetic mouse were randomly divided into model group, Metformin group (250mg/kg), pine bark procyanidins extract high-dose group (400mg/kg), middle-dose group (200mg/kg) and low-dose group (100mg/kg). Fasting blood glucose was measured after continuous intragastric administration 8 weeks. Blood samples were taken out from the tail of diabetic mice to measure fasting blood glucose; Then blood samples were taken out from the eyeball to measure the serum activity of superoxide dismutase (SOD), INS content, MDA content and blood lipid level. Results: Pine bark procyanidins extract high and middle-dose group can significantly lower the blood glucose level in STZ induced diabetic mice; Serum INS content in pine bark procyanidins extract high-dose group was higher than the model group significantly (p<0.05); Serum SOD content in pine bark procyanidins extract high and middle-dose group was higher than the model group significantly (p<0.05); Serum MDA content in pine bark procyanidins extract high-dose group was lower than the model group significantly (p<0.05); TG, TC in pine bark procyanidins extract middle-dose group and LDL-C content in pine bark procyanidins extract high-dose group were lower than the model group significantly (p<0.05); HDL-C content in pine bark procyanidins extract high-dose group was higher than the model group significantly (p<0.05). Conclusion: The pine bark procyanidins extract had a significant effects on reducing blood glucose, antioxidation and improving blood lipid level in STZ induced diabetic mice.
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关键词
Pine bark procyanidins extract,Diabetes,Blood glucose,Blood lipid,Antioxidation
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