Effects of pine bark procyanidins extract on blood glucose, blood lipid and antioxidation in diabetic mice

Objective: To study the effects of pine bark procyanidins extract on blood glucose, blood lipid and antioxidation in diabetic mice. Methods: Diabetic mice model was made by intraperitoneal injection of Streptozotocin (STZ). Diabetic mouse were randomly divided into model group, Metformin group (250mg/kg), pine bark procyanidins extract high-dose group (400mg/kg), middle-dose group (200mg/kg) and low-dose group (100mg/kg). Fasting blood glucose was measured after continuous intragastric administration 8 weeks. Blood samples were taken out from the tail of diabetic mice to measure fasting blood glucose; Then blood samples were taken out from the eyeball to measure the serum activity of superoxide dismutase (SOD), INS content, MDA content and blood lipid level. Results: Pine bark procyanidins extract high and middle-dose group can significantly lower the blood glucose level in STZ induced diabetic mice; Serum INS content in pine bark procyanidins extract high-dose group was higher than the model group significantly (p<0.05); Serum SOD content in pine bark procyanidins extract high and middle-dose group was higher than the model group significantly (p<0.05); Serum MDA content in pine bark procyanidins extract high-dose group was lower than the model group significantly (p<0.05); TG, TC in pine bark procyanidins extract middle-dose group and LDL-C content in pine bark procyanidins extract high-dose group were lower than the model group significantly (p<0.05); HDL-C content in pine bark procyanidins extract high-dose group was higher than the model group significantly (p<0.05). Conclusion: The pine bark procyanidins extract had a significant effects on reducing blood glucose, antioxidation and improving blood lipid level in STZ induced diabetic mice.