Low-grade BRAF V600E mutant oligodendroglioma-like tumors of children may show EGFR and MET amplification

Pediatric low-grade gliomas were shown to be characterized by an array of distinct molecular aberrations. The recent cIMPACT-4 consensus proposed pediatric low-grade gliomas of the diffuse type to be characterized by distinct molecular changes rather than distinct histological features (2). Very recently, Fukuoka et al. described a small series of pediatric oligodendroglioma-like tumors with BRAF V600E mutations (3). Interestingly, they exhibited molecular changes usually associated with adult high grade gliomas: chromosome instability, chromosome 7 gains and chromosome 10 loss, but had an indolent natural history.