Double layer artificial blood vessel and preparation method thereof

The invention discloses a mesoporous miRNAs controlled-release nanosphere/heparin composite modified double-layer artificial blood vessel and a preparation method thereof. An inner layer of the bloodvessel is a mesoporous miRNAs controlled-release nanosphere/heparin composite modified degradable nanofiber layer, and an outer layer is a macroporous nanofiber layer; mesoporous miRNAs controlled-release nanosphere/heparin composite modified degradable nanofibers are spun by fibers, and the fibers are composed of a core layer and a skin layer; the core layer is composed of the components of miRNAs controlled-release nanospheres and heparin, and the skin layer is made of the degradable nanofibers. The functional nanofibers encapsulated with microRNAs controlled-release nanospheres and heparinin the fibers are prepared in the inner layer by a coaxial technology, the inner layer makes contact with blood to achieve the purpose of rapid endothelialization. The outer layer is composed of a macroporous layer prepared by a thermally induced phase separation technology. The double-layer artificial blood vessel provided by the invention has good tissue compatibility and biomechanical properties.