Site-Selective Halogenation On Meso-Mesityl Substituents Of 10,20-Dimesityl-5,15-Diazaporphyrins With An Aux3/Agotf Combination

We have developed site-selective bromination on the mesityl substituents of 10,20-dimesityl-5,15-diazaporphyrins. Treatment of 10,20-dimesityl-5,15-diazaporphyrin and its nickel(II) complex with a combination of AuBr3/AgOTf induced selective bromination on the mesityl groups. These brominated products can be employed for late-stage modification of the aryl substituents.