Polymorphism Rs6478109 In Thetnfsf15gene Contributes To The Susceptibility To Crohn'S Disease But Not Ulcerative Colitis: A Meta-Analysis

Objective Polymorphisms in the tumor necrosis factor superfamily 15 (TNFSF15) gene contribute to susceptibility to inflammatory bowel disease (IBD). However, associations betweenTNFSF15rs6478109, rs7869487, and rs7865494 polymorphisms and IBD remain unclear. Methods Eligible articles were retrieved from the PubMed, EMBASE, Web of Science, and CNKI databases through 20 March 2020. Pooled odds ratios (ORs) with 95% confidence intervals (CIs) were calculated to evaluate the relationships ofTNFSF15polymorphisms with IBD susceptibility. Results Under the recessive model,TNFSF15rs6478109 was associated with IBD risk (OR = 0.56; 95% CI: 0.35, 0.92). Stratification analyses based on the type of disease-Crohn's disease (CD) or ulcerative colitis (UC)-revealed a significant association under the allelic and recessive models betweenTNFSF15rs6478109 and CD (allelic model: OR = 0.84, 95% CI: 0.71, 0.99; recessive model: OR = 0.44, 95% CI: 0.22, 0.87) but not UC. Stratification by ethnicity indicated a significantly decreased risk of IBD in Asian populations withTNFSF15rs6478109 under the recessive model (OR = 0.56, 95% CI: 0.35, 0.92). Conclusions Our meta-analysis suggested that under the allelic and recessive models, theTNFSF15rs6478109 polymorphism was likely protective for CD but not UC in the Asian population.