Probing the Structure–Function relationship and amyloidogenic propensities in natural variants of apolipoprotein A-I
Biochemistry and Biophysics Reports(2020)
摘要
•Several apoA-I mutants are associated with systemic amyloidosis.•Structure–function analysis of five apoA-I variants and wild-type protein was done.•Point mutations alter the physicochemical behavior and conformation of the variants.
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关键词
Apolipoprotein A-I,Mutation,Amyloid,Atherosclerosis
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