Probing the Structure–Function relationship and amyloidogenic propensities in natural variants of apolipoprotein A-I

Farah Ma'arfi,Subhash Chandra Prasad,Jamal e Fatima,Mohd Yasir Khan,Snober S. Mir,Mohd Aslam Yusuf

Biochemistry and Biophysics Reports（2020）

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摘要

•Several apoA-I mutants are associated with systemic amyloidosis.•Structure–function analysis of five apoA-I variants and wild-type protein was done.•Point mutations alter the physicochemical behavior and conformation of the variants.

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关键词

Apolipoprotein A-I,Mutation,Amyloid,Atherosclerosis

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