Polyvalent Effect Enhances Anti-influenza Virus Activity
ADVANCES IN APPLIED BIOTECHNOLOGY(2018)
摘要
An efficient synthesis of poly-valent difluorinated zanamivir modified polymer as strong inhibitor of influenza virus was reported. Specifically, the mono difluorinated zanamivir with an azide linker was attached on alkynlated [poly (methyl vinyl ether-alt-maleic anhydride)] via “Click Chemistry” to afford polyvalent glycopolymer. The neuraminidase inhibition assay against H7N9 virus like particle showed an enhanced anti-influenza virus activity with IC50 value at least 1000 fold better than that of the difluorinated zanamivir monomer.
更多查看译文
关键词
Polyvalent effect, Difluorozanamivir, Click chemistry, Antiviral inhibitor
AI 理解论文
溯源树
样例
![](https://originalfileserver.aminer.cn/sys/aminer/pubs/mrt_preview.jpeg)
生成溯源树,研究论文发展脉络
Chat Paper
正在生成论文摘要