Potentials and challenges of Levodopa particle formulation for treatment of Parkinson?s disease through intranasal and pulmonary delivery

•Developments and challenges of Levodopa for inhalation drug delivery are reviewed•Advantages of inhalation delivery of Levodopa to treat Parkinson’s disease are shared•Particle characteristics, synthesis methods and pharmacokinetic results are presented•Successful formulations and gaps in the field are reported