Pharmacokinetic comparative study of GAS with different concentration of tetramethylpyrazine and ferulic acid on liver–yang hyperactivity migraine model by blood–brain microdialysis method

•Aconite extract oralled which was based on the migraine model, because of that, a dual model was created.•The pharmacokinetic effects containg tetramethylpyrazine and ferulic acid on GAS of gastrodia elata was studied.•The blood-brain microdialysis method was used to study the pharmacokinetics of constituents of traditional Chinese medicine.