Clinical Probe of Cyp2C8*2 Mutants in a Malaria Hyperendemic Zone: Evidence from North-Central, Nigeria.
Acta medica (Hradec Kralove)(2020)
摘要
A remarkable inter-ethnic differences in autosomal recessive CYP2C8*2 allele was observed. By implication, there is a gradual incursion of genetic drift for poor CQ and AQ-Artemisinin metabolizers among the inhabitants.
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关键词
Amodiaquine-Artemisinin combination therapy,CYP2C8*2,Chloroquine,Hausa,Igbo,Nigeria,Plasmodium falciparum,Yoruba
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