Drivers Of Crizotinib Resistance In Alk(+) Alcl

BLOOD(2020)

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摘要
In this issue of Blood, Prokoph et al(1) seek to identify mechanisms by which ALK(+) anaplastic large cell lymphoma (ALCL) cells develop resistance to the ALK inhibitor crizotinib. Their findings implicate a novel and potentially targetable interleukin-10 (IL-10) receptor-dependent autocrine loop that bypasses ALK signaling.
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