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Photoaffinity Labeling and Quantitative Chemical Proteomics Identify LXRβ As the Functional Target of Enhancers of Astrocytic Apoe

Uthpala Seneviratne,Zhen Huang,Christopher W. am Ende,Todd W. Butler,Leah Cleary,Erica Dresselhaus,Edelweiss Evrard,Ethan L. Fisher, Michael E. Green,Christopher J. Helal,John M. Humphrey,Lorraine F. Lanyon,Michael Marconi,Paramita Mukherjee,Simone Sciabola,Claire M. Steppan,Emily K. Sylvain,Jamison B. Tuttle,Patrick R. Verhoest,Travis T. Wager,Longfei Xie,Gayathri Ramaswamy,Douglas S. Johnson,Martin Pettersson

SSRN Electronic Journal（2020）

Cited 18|Views49
Key words
chemical proteomics,target identification,CETSA,apoE,LXRβ,phenotypic screening,MOA
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