Stereoselective Construction Of Gamma-Lactams Via Copper-Catalyzed Borylacylation

A versatile and highly stereoselective borylative cyclization to generate polyfunctionalized gamma-lactams has been developed. The stereoselective synthesis of these key ring systems is crucial due to their ubiquity in natural products. We report the diastero- and enantioselective construction of di- and trisubstituted gamma-lactam cores, with examples containing an enantioenriched quaternary carbon.