Human repeat element DNA methylation as markers for early diagnosis of liver cancer and application thereof

The invention discloses an human repeat element DNA methylation as markers for early diagnosis of liver cancer and an application thereof.The invention belongs to the field of biological detection, and relates to markers for liver cancer and the application thereof.These markers are selected from one or more of the CpG sites modified at positions 64 on AluYg6,72,231 on AluSp,447,493,673 on L1HS,380,448 on L1,230 on AluYba3a2,1569 on LSAU, and 446 on LTR12E in Repbase data published by the Genetic Information Research Institute (GIRI).The invention further provides a system for diagnosing livercancer or predicting the risk of liver cancer by using the combination of the markers.The methylation states of the markers are obviously different in tumor tissues and non-tumor tissues; the methylation of the markers is low in the tumor tissues, and the accuracy rate of distinguishing whether or not a patient suffers from liver cancer in a test set by the marker combination reaches 90 percent.