Identification of critical formulation parameters affecting the in vitro release, permeation, and rheological properties of the acyclovir topical cream (vol 590, 119914, 2020)

Pareto charts of the standardized effects of various formulation variables on the (a) acyclovir release rate (mg/cm2 h0.5) and (b) acyclovir retained by the skin (µg/cm2). The chart shows estimate coefficients, t ratio and Prob > t values of the variables. The two vertical blue lines represent the significance limit of p = 0.05. Response surface (c and d) plots of the investigated responses, respectively.