Preparation method for anti infectious nano collagen/ calcium phosphate bone repair material
user-5ebe28444c775eda72abcdcf(2011)
摘要
The invention discloses a preparation method for an anti-infectious nano collagen/ calcium phosphate bone repair material, and belongs to the field of biomedical materials. The method comprises the following steps of: slowly dripping solution containing calcium ions and aqueous solution containing phosphate radical ions into acid-soluble collagen solution, dripping NaOH solution to regulate the pH value, performing freeze drying, grinding to obtain dry powder for later use, dissolving poly-L-lactic acid in 1,4-dioxane, stirring for a certain time, mixing the solution and the dry powder uniformly, finally adding vancomycin, stirring uniformly, removing the solvent by adopting a freeze drying method, and preparing the anti-infectious nano collagen/ calcium phosphate bone repair material. The prepared bone repair material has excellent biocompatibility, infection resistance and a micro-structure similar to human body.
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关键词
Solvent,Phosphate,Freeze-drying,Dissolution,Chemistry,Chemical engineering,Calcium,Bone healing,Biocompatibility,Aqueous solution
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