Endothelial-Specific Overexpression of Histone Deacetylase 2 Protects Mice against Endothelial Dysfunction and Atherosclerosis.

Daijiro Hori,Yohei Nomura,Mitsunori Nakano,Mingming Han,Anil Bhatta,Ke Chen,Kei Akiyoshi,Deepesh Pandey

Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology（2020）

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摘要

HDAC2 protects against endothelial dysfunction and atherogenesis induced by oxidized lipids. Hence, overexpression or activation of HDAC2 represents a novel therapy for endothelial dysfunction and atherosclerosis. HDAC2-Tg mice provide an opportunity to determine the role of endothelial HDAC2 in vascular endothelial homeostasis.

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关键词

Atherosclerosis, Endothelial Dysfunction, HDAC2 (Histone deacetylase 2), OxLDL (Oxidized low-density lipoprotein), PCSK9 (Proprotein convertase subtilisin/kexin type 9), PWV (Pulse wave velocity)

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