Different combinations of GABA, BMP7, and Activin A induced the in vitro differentiation of rat pancreatic ductal stem cells into insulin-secreting islet-like cell clusters

Lang Guan Cun,Muhammad Waseem Ghani,Zhao Yi,Wu Jiang,Li Ye,Liu Bin,Muhammad Waseem Birmani,An Lilong,Xiao Mei

Life Sciences（2021）

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摘要

•Different combinations of growth factors reprogrammed PDESCs.•PDESCs can be differentiated to the ICCs through growth factor inducement.•Induced ICCs contained insulin-secreting β-like cells.

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A,Akt,ANOVA,ALK3,B,BMP,BSA,DTZ,DMSO,DMEM,EGF,FACS,FBS,FDA,G,GABA,GSIS,HBSS,hNEPT,Ins1,ICCs,ELISA,PDESCs,PBS,Pdx1,PI3K,qPCR,RPMI,SD,TGFβ

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