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SH3KBP1 scaffolds endoplasmic reticulum and controls skeletal myofibers architecture and integrity

Alexandre Guiraud,Emilie Christin,Nathalie Couturier,Carole Kretz-Remy,Alexandre Janin,Alireza Ghasemizadeh,Anne-Cécile Durieux,David Arnould,Norma Beatriz Romero,Mai Thao Bui,Vladimir L. Buchman,Laura Julien,Marc Bitoun,Vincent Gache

biorxiv（2020）

Cited 0|Views17
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Abstract
Altogether our results identify SH3KBP1 as a new regulator of myonuclear domains establishment in the early phase of muscle fibers formation through ER scaffolding and later in myofibers integrity through T-tubules scaffolding/maintenance.
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Key words
skeletal myofibers architecture,endoplasmic reticulum
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