Platelet counts predict prognosis in IPF, but are not the main source of pulmonary TGFβ1

Deborah. L. W. Chong,Theresia A. Mikolasch,Jagdeep Sahota,Carine Rebeyrol,Helen S. Garthwaite,Helen L. Booth,Melissa Heightman,Ricardo J. José,Akif A. Khawaja,Myriam Labelle,Christopher J. Scotton,Joanna C. Porter

biorxiv（2020）

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摘要

Our results demonstrate for the first-time that platelet-derived TGFβ1 is redundant in driving pulmonary fibrosis in an animal model. However, platelets can predict mortality in IPF implicating other platelet-derived mediators, such as CCL5, in promoting human IPF disease.

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关键词

platelet,prognosis

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