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Compensation of physiological motion enables high-yield whole-cell recording in vivo

William M. Stoy,Bo Yang, Ali Kight,Nathaniel C. Wright,Peter Y. Borden,Garrett B. Stanley,Craig R. Forest

Journal of Neuroscience Methods（2021）

Cited 3|Views16
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Abstract
•Gigaseal formation shows a strong dependence on pipette-cell distance.•Tissue motion can be predicted and compensated with a feed-forward control system.•Compensation for tissue motion improves whole-cell success rates in the thalamus.
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Key words
Motion compensation,Whole-cell,Patch clamp,In vivo,Automated patching,Autopatching,Optogenetics
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