Structural Analysis of Different LINC Complexes Reveals Distinct Binding Modes
Journal of Molecular Biology（2020）
摘要
•High-resolution structures of SUN2-KASH complexes reveal two distinct binding modes.•A SUN2 trimer can engage different KASH-types simultaneously.•Apo-SUN may exist in a self-locked KASH-binding-inhibited state.
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关键词
SUN proteins,KASH proteins,nucleo-cytoplasmic communication,mechanotransduction,nuclear envelope
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