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Continuum dynamics and statistical correction of compositional heterogeneity in multivalent IDP oligomers resolved by single-particle EM

Barmak Mostofian,Russell McFarland,Aidan Estelle,Jesse Howe,Elisar Barbar,Steve L. Reichow,Daniel M. Zuckerman

Journal of Molecular Biology（2022）

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Abstract
•Semi-ordered multivalent IDPs are highly prevalent complexes in the cell.•These difficult targets studied by novel single-particle EM distribution analysis.•Conformational and compositional heterogeneity disentangled and quantified.•Validated and applied to multivalent IDPs bound to the universal hub protein, LC8.•This automated approach may be applied to other IDP systems.
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Key words
intrinsically disordered proteins (IDP),multivalency,LC8,electron microscopy (EM),single-molecule
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