Primary Human Colonic Mucosal Barrier Crosstalk with Super Oxygen-Sensitive Faecalibacterium prausnitzii in Continuous Culture

Jianbo Zhang,Yu-Ja Huang, Jun-Young Yoon, John Kemmitt,Charles Wright,Kirsten Schneider,Pierre Sphabmixay,Victor Hernandez-Gordillo,Steven J. Holcomb,Brij Bhushan, Gar Rohatgi, Kyle Benton,David Carpenter,Jemila C. Kester,George Eng,David T. Breault,Omer Yilmaz,Mao Taketani,Christopher A. Voigt,Rebecca L. Carrier,David L. Trumper,Linda G. Griffith

Med（2021）

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摘要

Development of a model of the primary human colon mucosal barrierSuper oxygen-sensitive F. prausnitzii and colon epithelium co-cultured for up to 4dF. prausnitzii exerts anti-inflammatory effects through HDAC and the TLR-NFKB axisF. prausnitzii reduces TLR3/TLR4 expression in colon epithelium via butyrate

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