Testing the CRISPR-Cas9 and glmS ribozyme systems in Leishmania tarentolae
Molecular and Biochemical Parasitology(2021)
摘要
•Establishment of a simple, fast and efficient CRISPR-Cas9 system for L. tarentolae•Confirmation that the potential drug target “Erv” is essential in Leishmania•Establishment of a constitutive glmS knock-down system for episomal constructs•Establishment of an inducible glmS knock-down system for episomal constructs•Chromosomal glmS-tagging caused no detectable phenotype
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关键词
Leishmania,CRISPR-Cas9,glmSribozyme,knock-down,cell culture
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