Testing the CRISPR-Cas9 and glmS ribozyme systems in Leishmania tarentolae

Gino L. Turra,Luzia Schneider,Linda Liedgens,Marcel Deponte

Molecular and Biochemical Parasitology（2021）

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摘要

•Establishment of a simple, fast and efficient CRISPR-Cas9 system for L. tarentolae•Confirmation that the potential drug target “Erv” is essential in Leishmania•Establishment of a constitutive glmS knock-down system for episomal constructs•Establishment of an inducible glmS knock-down system for episomal constructs•Chromosomal glmS-tagging caused no detectable phenotype

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关键词

Leishmania,CRISPR-Cas9,glmSribozyme,knock-down,cell culture

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