Early defects in lysosomal storage diseases disrupt excitatory synaptic transmission
biorxiv(2020)
摘要
Together, our results demonstrate that lysosomal storage causes alterations in synaptic structure and abnormalities in neurotransmission originating from disrupted vesicular transport and preceding the first cognitive symptoms and suggest drugs known to affect synaptic transmission can be potentially applied to treat behavioral and cognitive defects in neurological LSD patients.
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关键词
synaptic transmission,mucopolysaccharidosis,heparan sulfate,acetyl-CoA: α,-glucosaminide N-acetyltransferase
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