Noncanonical targeting contributes significantly to miRNA-mediated regulation
bioRxiv (Cold Spring Harbor Laboratory)(2020)
摘要
Almost a third of genes we predict to be miRNA targets lack sequence complementarity to the miRNA seed region (noncanonical targets). These noncanonical targets have higher complementary with the miRNA 3’ end. The impact of miRNAs on the levels of their canonical or noncanonical targets is identical supporting the relevance of this poorly explored mechanism of targeting.
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关键词
noncanonical targeting,mirna-mediated
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