The Enrichment Of Breakpoints In Late-Replicating Chromatin Provides Novel Insights Into Chromoanagenesis Mechanisms Nicolas Chatron , Giuliana Giannuzzi , Pierre-Antoine Rollat-Farnier , Flavie Diguet , Eleonora Porcu , Tony Yammine , Kevin Uguen , Zohra-Lydia Bellil , Julia Lauer Zillhardt , Arthur Sorlin , Flavie Ader , Alexandra Afenjar , Joris Andrieux , Claire Bardel , Eduardo Calpena , Sandra Chantot-Bastaraud , Patrick Callier , Nora Chelloug , Emilie Chopin , Marie-Pierre Cordier , Christèle Dubourg , Laurence Faivre , Françoise Girard , Solveig Heide , Yvan Herenger , Sylvie Jaillard , Boris Keren , Samantha J. L. Knight , James Lespinasse , Laurence Lohmann , Nathalie Marle , Reza Maroofian , Alice Masurel-Paulet , Michèle Mathieu-Dramard , Corinne Metay , Alistair T. Pagnamenta , Marie-France Portnoï , Fabienne Prieur , Marlène Rio , Jean-Pierre Siffroi , Stéphanie Valence , Jenny C. Taylor , Andrew O. M. Wilkie , Patrick Edery , Alexandre Reymond , Damien Sanlaville , Caroline Schluth-Bolard EUROPEAN JOURNAL OF HUMAN GENETICS（2020）
Abstract
The enrichment of breakpoints in late-replicating chromatin for both constitutional and cancer provides an orthogonal support to the premature chromosome condensation hypothesis that was put forward to explain .
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Key words
chromoanagenesis, chromothripsis, replication-timing, lamina-associated domains, chromosomal breakpoint
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