Quantitative Trait Loci Mapped For Tcf21 Binding, Chromatin Accessibility And Chromosomal Looping In Coronary Artery Smooth Muscle Cells Reveal Molecular Mechanisms Of Coronary Disease Loci

Quanyi Zhao,Michael Dacre,Trieu Nguyen,Milos Pjanic,Boxiang Liu,Dharini Iyer,Paul Cheng,Robert Wirka,Juyong Brian Kim,Hunter B Fraser,Thomas Quertermous

ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY（2020）

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摘要

Introduction: To investigate the epigenetic and transcriptional mechanisms of coronary artery disease (CAD) risk, as well as the functional regulation of chromatin structure and function, we have c...

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关键词

coronary artery disease,smooth muscle cells,quantitative trait locus,TCF21,chromosomal looping,chromatin accessibility

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